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Get PriceA method for disrupting cells and/or tissues employs a disrupter with a disruption element having an outer dimension that is slightly smaller than the inside dimension of a container in which a sample is place to be disrupted. Devices for disrupting cells and/or tissues are also presented. The device and methods are used in processes such as the extraction of nucleic acids.
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Get Pricemortar and pestles, sonicators, mixer mills, and vortexers are several of the more common tools used for mechanical and physical disruption. Sample disruption, or homogenization, is not the most exciting methodology to examine, but none-the-less it does have significant impact on the end results of a process. Though used daily and extensively,
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Get PriceThe mixer mill MM 400 is a compact versatile bench-top unit, which has been developed specially for dry, wet and cryogenic grinding of small amounts of sample. It can mix and homogenize powders and suspensions in only a few seconds. It is also perfectly suitable for the disruption of biological cells as well as for DNA/RNA and protein extraction. With its high performance and great flexibility
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Get PriceEffective sample disruption and homogenization is an absolute requirement for all RNA purification procedures. Incomplete disruption and homogenization reduces RNA yields and can lead to bias in RNA profiling. Sample disruption does make the RNA accessible to RNases, so it is crucial to perform this step under conditions that denature RNases.
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Get PriceA Practical Guide to ISO 10993-5 Cytotoxicity Posted in Regulatory and Compliance by mddiadmin on April 1, 1998 Medical Device Diagnostic Industry Magazine MDDI Article Index An MDDI April 1998 Column ISO 10993 Required for all types of medical devices, cytotoxicity testing is a key element of the international standards.
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